Korean J Med.  2009 Oct;77(4):517-521.

Cerebral sinovenous thrombosis associated with nephrotic syndrome

• Kim HJ
• Jung DE
• Byun SJ
• Lee YM
• Lee JE
• Ahn SH
• Song JH

Abstract

Nephrotic syndrome is associated with proteinuria, hypoalbuminemia, edema, hyperlipidemia, and thromboembolic complications. Thromboembolic complications of nephrotic syndrome are common, especially in the renal vein, while cerebral venous thrombosis is a less frequent complication of minimal change nephrotic syndrome. The pathophysiology remains unclear, but various changes in coagulant and anticoagulant factors may be responsible. We report a case of cerebral venous thrombosis associated with nephrotic syndrome. A 19-year-old man was admitted with a headache and nausea. Cerebral thrombosis was diagnosed on brain computed tomography and magnetic resonance imaging. He recovered gradually after treatment with anticoagulants and achieved control of the nephrotic syndrome. A discussion of this case, coupled with a review of the literature, emphasizes that an early diagnosis is essential for anticoagulation therapy and a successful outcome.

Keyword

Cerebral thrombosis; Nephrotic syndrome

MeSH Terms

Anticoagulants
Brain
Early Diagnosis
Edema
Headache
Humans
Hyperlipidemias
Hypoalbuminemia
Intracranial Thrombosis
Magnetic Resonance Imaging
Nausea
Nephrosis, Lipoid
Nephrotic Syndrome
Proteinuria
Renal Veins
Thrombosis
Venous Thrombosis
Young Adult
Anticoagulants