Korean J Med.  2009 Oct;77(4):435-443.

IgA nephropathy over 40 years

• Ihm CG

Abstract

IgA nephropathy is characterized by the predominant deposition of IgA in a granular fashion diffusely in the mesangial zones of glomeruli. IgA nephropathy was first described over four decades ago and is now the most common form of primary glomerular disease. Much progress has been made in the elucidation of potential pathogenetic mechanisms such as undergalactosylated IgA1 as well as in the fields of clinical features, prognosis, and treatment. This knowledge is being applied in the development of new diagnostic methods and hopefully in the future the creation of novel and rational therapeutic approaches.

Keyword

IgA nephropathy; Pathogenesis; Undergalactosylated IgA1; Bone marrow disorder; Chronic renal failure

MeSH Terms

Glomerulonephritis, IGA
Immunoglobulin A
Kidney Failure, Chronic
Prognosis
Immunoglobulin A