Korean J Med.  2009 May;76(5):632-636.

A case of relapsing polychondritis and pyoderma gangrenosum in a patient with Down's syndrome

• Cho YD
• Lee YA
• Park JN
• Lee SH
• Yang HI
• Hong SJ

Abstract

Relapsing polychondritis (RP) is a rare multisystem disorder of unknown etiology that affects cartilaginous tissues, such as the auricular, nasal, and laryngotracheal cartilages. It may be accompanied by a wide spectrum of skin lesions, including erythema nodosum, erythema multiforme, and panniculitis. Pyoderma gangrenosum is a rare chronic cutaneous disease that usually presents as a painful nodule or pustule and progressively forms an enlarging ulcer. It may be associated with inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythromatosus, leukemia, and myeloproliferative disorders. Pyoderma gangrenosum is rarely associated with RP. RP and pyoderma gangrenosum have been reported in a patient with myelodysplastic syndrome (MDS), and the appearance of skin lesions in MDS may herald its progression to acute myeloid leukemia. Here, we report the first case of RP coexisting with pyoderma gangrenosum in a patient with Down's syndrome.

Keyword

Relapsing polychondritis; Pyoderma gangrenosum; Down's syndrome

MeSH Terms

Arthritis, Rheumatoid
Cartilage
Down Syndrome
Erythema Multiforme
Erythema Nodosum
Humans
Inflammatory Bowel Diseases
Leukemia
Leukemia, Myeloid, Acute
Myelodysplastic Syndromes
Myeloproliferative Disorders
Panniculitis
Polychondritis, Relapsing
Pyoderma
Pyoderma Gangrenosum
Skin
Ulcer