Korean J Med.  2009 Jun;76(6):682-684.

Implication of aspirin resistance: Simple laboratory finding or important clinical criteria?

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Gyeongsang National University Hospital, Jinju, Korea.

Abstract

Aspirin resistance defined by light transmittance aggregometry (LTA) or urinary 11-dehydro-thromboxane B2 has been associated with an increased risk of adverse clinical events. However, aspirin resistance based on the point-of-care VerifyNow-Aspirin assay (aspirin reaction unit > or = 550) shows poor sensitivity compared with LTA. In aspirin-treated patients, activation by cyclooxygenase- independent pathways may be associated with residual platelet reactivity, which may cause adverse clinical outcomes in some portion. A large-scale, prospective study using several platelet function assays should be performed to establish the long-term clinical significance of antiplatelet resistance in Korean patients treated with coronary stenting. Accordingly, we can apply tailored antiplatelet therapy in resistant patients.

Keyword

Aspirin resistance; VerifyNow-Aspirin; Tailored antiplatelet therapy
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