Nucl Med Mol Imaging.  2016 Jun;50(2):99-101. 10.1007/s13139-015-0369-6.

Application of a Small Molecule Radiopharmaceutical Concept to Improve Kinetics

• Jeong JM

• KMID: 2256995
• DOI: http://doi.org/10.1007/s13139-015-0369-6

Abstract

Recently, large molecules or nanoparticles are actively studied as radiopharmaceuticals. However, their kinetics is problematic because of a slow penetration through the capillaries and slow distribution to the target. To improve the kinetics, a two-step targeting method can be applied by using small molecules and very rapid copper-free click reaction. Although this method might have limitations such as internalization of the first targeted conjugate, it will provide high target-to-nontarget ratio imaging of radiopharmaceuticals.

MeSH Terms

Capillaries
Kinetics*
Methods
Nanoparticles
Radiopharmaceuticals
Radiopharmaceuticals