Korean J Med.  2007 Dec;73(6):565-574.

The association of sex hormones and the metabolic syndrome in apparently healthy Korean male adults

• Kim S
• Rhee EJ
• Seok HS
• Choi YG
• Chung WG
• Lee DY
• Kim SY
• Jung CH
• Park CY
• Lee WY
• Oh KW
• Park SW
• Kim SW

Abstract

BACKGROUND: Recent studies report an association of decreased testosterone levels with type 2 diabetes mellitus, insulin resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome. However, studies on correlations of testosterone with dyslipidemia, insulin resistance and metabolic syndrome in Koreans are scarce. We analyzed the relationship between levels of sex hormones and metabolic syndrome, lipid profiles and insulin resistance in Korean adult males.
METHODS
A total of 289 males were selected among the participants in a medical health check-up from June to July 2003 at Kangbuk Samsung Hospital Health Promotion Center. Metabolic syndrome was defined according to the Modified National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) III. The serum total testosterone level was measured using a radioimmunoassay and sex hormone binding globulin (SHBG) was measured using a radioimmunometric assay.
RESULTS
The prevalence of metabolic syndrome was 15.6% and the total testosterone level showed a significant correlation with the levels of high-density lipoprotein cholesterol, fasting insulin, and uric acid even after adjustment for age and body mass index (BMI). Serum SHBG showed a significant correlation with diastolic blood pressure, uric acid, triglyceride, fasting insulin and insulin resistance indices. In logistic regression analysis in which age, drinking history, and smoking status were adjusted, decreased total testosterone and SHBG levels as well as increased estradiol levels showed significant correlations with an increased prevalence of metabolic syndrome.
CONCLUSION
This study shows that decreased total testosterone and SHBG levels and an increased estradiol level were significantly correlated with increased metabolic syndrome prevalence and dyslipidemia in healthy Korean male adults. Further studies are suggested for the association of sex hormone replacement and the changes in the metabolic status.

Keyword

Testosterone; SHBG; Metabolic syndrome; Insulin resistance

MeSH Terms

Adult*
Blood Pressure
Body Mass Index
Cholesterol
Diabetes Mellitus, Type 2
Drinking
Dyslipidemias
Education
Estradiol
Fasting
Gonadal Steroid Hormones*
Health Promotion
Humans
Hyperinsulinism
Insulin
Insulin Resistance
Lipoproteins
Logistic Models
Male*
Prevalence
Radioimmunoassay
Sex Hormone-Binding Globulin
Smoke
Smoking
Testosterone
Triglycerides
Uric Acid
Cholesterol
Estradiol
Gonadal Steroid Hormones
Insulin
Lipoproteins
Sex Hormone-Binding Globulin
Smoke
Testosterone
Uric Acid