Korean J Blood Transfus.  1998 Jun;9(1):111-116.

A Case of Rh Negative Brother and Sister, Both of Whose Parents Were Rh Positive

Affiliations
  • 1Department of Clinical Pathology, Sunlin Hospital, Pohang, Korea.
  • 2Department of Chest Surgery, College of Medicine, DongGuk University, Korea.

Abstract

The authors have experienced a case of Rh negative brother and sister, both of whose parents were Rh positive. On the testing by five major Rh antisera (anti D, anti C, anti E, anti c, and anti e), the phenotypes of his father and mother were each DccEe and DCCee, those of the brother and sister were ddCcee. Considering the possible genotypes, their genotype was only one Cde/cde in twenty-four combinations. The possibility of that Rh negative (Cde/cde) child could successively born by those parents was 0.00017, with reference to Rh haplotype frequency in Korea. So, this case is rare and showed that Rh negative child could be born by Rh positive parents.

Keyword

Rh negative brother and sister

MeSH Terms

Child
Fathers
Genotype
Haplotypes
Humans
Immune Sera
Korea
Mothers
Parents*
Phenotype
Siblings*
Immune Sera
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