Korean J Hematol.  2009 Dec;44(4):261-267. 10.5045/kjh.2009.44.4.261.

A Case Report of Helicobacter Pylori Negative Gastric MALT Lymphoma with Monoclonal Gammopathy

  • 1Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea. jspark65@ajou.ac.kr
  • 2Department of Pathology, Ajou University School of Medicine, Suwon, Korea.
  • 3Department of Surgery, Ajou University School of Medicine, Suwon, Korea.
  • 4Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea.


Lymphomas of mucosa-associated lymphoid tissue (MALT) comprise 7% of all newly diagnosed non-Hodgkin's lymphomas. Helicobacter pylori (H. pylori) negative gastric MALT lymphomas account for 28 to 45% of gastric MALT lymphomas. H. pylori infection has a close relationship with most gastric low-grade B cell lymphomas of the MALT type. Monoclonal gammopathy can be seen in 36% of the patients and negatively associated with responses to eradication of H. pylori in gastric MALT lymphoma. Here, we describe a case of H. pylori negative MALT lymphoma that arose from the stomach with massive plasmacytic differentiation mimicking an extramedullary plasmacytoma with monoclonal gammopathy, and that was cured by total gastrectomy, chemotherapy and radiotherapy.


Helicobacter pylori negative; Gastric B cell lymphoma of mucosa-associated lymphoid tissue type; Monoclonal gammopathy
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