Korean J Med.  1997 Jan;52(1):49-57.

A Study of Ten-Year Follow-Up for Immune Responses of Plasma Derived HB Vaccine(Hepavax-B(R))

• Kim HS
• Choi SK
• Kim JH
• Cho D
• Suh SP
• Kim SJ

Abstract

OBJECTIVES
There are much controversy about the duration of antibody persistence, necessity and time of booster for hepatitis B vaccine(HB vaccine). The long term follow-up study is lack in Korea. Therefore this study is designed for evaluating the long-term immunogenicity of HB vaccine, necessity and time of booster vaccination.
METHODS
The plasma derived HB vaccine (He-pavax-B(R)) was administered to healthy volunteers (28cases) as usual method. Secondary booster immunization was done at the 2nd year after primary vaccination in 6 cases(anti-HBs<10 mIU/ml). The serum transaminase levels, the HBsAg and anti-HBs were checked at the 9th month, 1st, 2nd, 3rd, 5th and 10th year after primary vaccination.
RESULTS
1) The positivity of anti-HBs (over 10mIU/ml) was 93%, 96%, 92% at the 3rd, 5th, 10th year respectively. In the children under 20 years old, it was 94Yo at the 3rd, 5th and 10th year without the secondary booster. 2) The good responders(anti-HBs>or=100mIU/ml) at the 9th month after primary vaccination are 21 cases (7%), low responders(anti-HBs: 10-100mIU/ml) 5 cases (18%), and non-responders(anti-HBsCONCLUSION
The booster administration of hepatitis B vaccine was not necessary for 10 years in the good responders or the children under 20 years old. But, the booster was necessary in low and non-responders for maintaining the titers of anti-HBs.

Keyword

Hepatitis B vaccine; Immune response

MeSH Terms

Adult
Child
Follow-Up Studies*
Healthy Volunteers
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B Vaccines
Humans
Immunization, Secondary
Korea
Plasma*
Vaccination
Young Adult
Hepatitis B Surface Antigens
Hepatitis B Vaccines