Korean J Biol Psychiatry.  2011 Aug;18(3):141-147.

Relationship between White Matter Changes and Cognitive Dysfunction in the Elderly with Subjective Memory Complaint

• Shin EY
• Jung HY
• Kim YR
• Lee SI
• Kim SG

Abstract

OBJECTIVES
The purpose of this study is to evaluate the relationship between the severity of white matter changes (WMC), risk factors and cognitive domains, including executive function profiles. METHOD: Forty nine subjects over 55 years with subjective memory complaints were assessed with MRI and neuropsychological tests. The WMC were assessed by MRI T2-FLAIR images and divided into 3 groups of mild vs. moderate vs. severe and 2 groups of mild-moderate vs. severe by using Mantyla's criteria and Fazeka's criteria. The risk factors were examined in hypertension, heart disease history and chemistry Lab. Medical conditions which affect to cognitive dysfunction and definite dementia were also excluded.
RESULTS
Comparing 3 groups, hypertension was identified as a risk factor of the WMC. Comparing 2 groups, total cholesterol and LDL were identified for as the risk factor of WMC. The severity of WMC was significantly associated with cognitive disturbances and their main effect on cognition was working memory and inhibition.
CONCLUSION
The risk factors of the WMC in the elderly were hypertension, hyperlipidemia. The severity of WMC appears to be associated with executive dysfunction in the elderly.

Keyword

White matter changes; Executive function; Cognition; Risk factor

MeSH Terms

Aged
Cholesterol
Cognition
Dementia
Executive Function
Heart Diseases
Humans
Hyperlipidemias
Hypertension
Memory
Memory, Short-Term
Neuropsychological Tests
Pyridines
Risk Factors
Thiazoles
Cholesterol
Pyridines
Thiazoles