Korean J Helicobacter Up Gastrointest Res.
2015 Jun;15(2):117-123. 10.7704/kjhugr.2015.15.2.117.
Endoscopic Appearances with a High Probability of Positive Biopsy in Follow-up Endoscopy of Gastric Mucosa-associated Lymphoid Tissue Lymphoma
- Affiliations
-
- 1Department of Gastroenterology, College of Medicine, The Catholic University of Korea, Seoul, Korea. isle@catholic.ac.kr
- 2Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 3Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 4Department of Hematology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- KMID: 2249860
- DOI: http://doi.org/10.7704/kjhugr.2015.15.2.117
Abstract
- BACKGROUND/AIMS
Remission of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is difficult due to pleomorphic and multifocal endoscopic findings. We investigated the relationship between endoscopic appearances and histological findings of patients followed up after curative treatment for the tumor.
MATERIALS AND METHODS
This retrospective study included 25 consecutive patients diagnosed with gastric MALT lymphoma, who were treated and underwent serial follow-up endoscopies with biopsies from June 2009 to March 2014 in Seoul St. Mary's Hospital. We reviewed the follow-up endoscopic findings at least 2 months after Helicobacter pylori eradication or chemoradiotherapy. Target biopsy sites were categorized according to their endoscopic appearance.
RESULTS
The mean follow-up period was 17.6 months; 76 endoscopies and 238 biopsies were performed. Positive biopsies were observed in 50 cases (21.0%). Tumor positivity was high in ulcerated lesions (2/3, 66.7%), erosion (1/5, 20.0%), discoloration (32/89, 36.0%), mucosal thickening (10/41, 24.4%) and ulcer scars (3/21, 14.3%). Conversely, lesions appearing normal showed low positivity (1/68, 1.5%) and was significantly lower compared with the aforementioned lesions (P<0.001).
CONCLUSIONS
Endoscopic appearances of depression, discoloration, mucosal thickening and ulcer scars were more likely to have tumor cells and should be targeted during follow up for gastric MALT lymphoma.
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