Korean J Biol Psychiatry.  2006 May;13(2):103-109.

Interactions of Vascular Risk Factors and Apolipoprotein E4 on Geriatric Depression

• Park HY
• Kim JM
• Shin IS
• Yang SJ
• Kim SW
• Kim SY
• Shin HY
• Yoon JS

Abstract

OBJECTIVE
Associations of vascular risk/disease or apolipoprotein E epsilon4(APOE4) with geriatric depression has been unclear at a population level. This study aimed to evaluate whether there would be interactions of vascular risk/disease and APOE4 on depression in a Korean elderly population.
METHODS
732 community residents aged 65 or over were assessed for depression(GMS), information on vascular risk/disease(reported stroke, transient ishemic attack, heart disease, hypertension, diabetes, smoking), examinations for vascular risk/disease(blood pressure, blood tests for glucose and lipid profiles, body size), APOE genotypes, demographic characteristics(age, gender, education), physical health, and cognitive function(MMSE).
RESULTS
Previous stroke and lower level of high density lipoprotein(HDL) cholesterol were significantly associated with geriatric depression independent of demographic characteristics, physical illnesses, and cognitive function. These associations were statistically significant only in those with APOE4, although the interaction terms didn't reach to statistical significance.
CONCLUSION
Associations between vascular risk/disease and geriatric depression might be more prominent in those with APOE4. However further research would be needed to clarify this issue.

Keyword

Stroke; Vascular risk; Apolipoprotein E; Depression; Elderly

MeSH Terms

Aged
Apolipoprotein E4*
Apolipoproteins E
Apolipoproteins*
Blood Pressure
Cholesterol
Depression*
Genotype
Glucose
Heart Diseases
Humans
Hypertension
Risk Factors*
Stroke
Apolipoprotein E4
Apolipoproteins
Apolipoproteins E
Cholesterol
Glucose