Korean J Dermatol.  2006 May;44(5):620-623.

A Case of Anticonvulsant Hypersensitivity Syndrome thought to be Caused by Lamotrigine

Affiliations
  • 1Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea. kwanglee@yumc.yonsei.ac.kr
  • 2Department of Dermatology, Ajou University College of Medicine, Suwon, Korea.

Abstract

Anticonvulsant hypersensitivity syndrome (AHS) is a rare and potentially life-threatening drug reaction, which has been associated with aromatic anticonvulsants such as phenytoin, carbamazepine, and phenobarbital. It is characterized by the triad of fever, rash and internal organ involvement, which mostly includes hepatitis. Histopathological findings usually show characteristic erythema multiforme. Lamotrigine is a new antiepileptic drug, chemically distinct from other anticonvulsant medication, however, AHS has recently been documented in patients treated with lamotrigine. We report a case of AHS in a 29-year-old man, thought to have been caused by the use of lamotrigine.

Keyword

Anticonvulsant hypersensitivity syndrome (AHS); Lamotrigine

MeSH Terms

Adult
Anticonvulsants
Carbamazepine
Erythema Multiforme
Exanthema
Fever
Hepatitis
Humans
Hypersensitivity*
Phenobarbital
Phenytoin
Anticonvulsants
Carbamazepine
Phenobarbital
Phenytoin
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