Korean J Dermatol.
2008 May;46(5):715-717.
Warfarin-induced Leukocytoclastic Vasculitis
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- 1Department of Dermatology, College of Medicine, Korea University, Seoul, Korea. kumcihk@korea.ac.kr
Abstract
- Leukocytoclastic vasculitis is a small vessel inflammatory disease, mediated mostly by deposition of immune complexes. Medications cause 10~24% of cases of leukocytoclastic vasculitic skin lesions, but warfarin has rarely been implicated. We report a case of warfarin-induced leukocytoclastic vasculitis in a 72-year-old woman which developed 45 days after warfarin medication. Palpable purpura, hemorrhagic vesicles, and ulcers developed on both lower legs. A skin biopsy showed characteristic features of leukocytoclastic vasculitis. Warfarin was replaced by clopidogrel, and the skin lesions gradually disappeared after 3 weeks.
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