Korean J Dermatol.  2008 Jun;46(6):742-748.

Expression of CD133, CD24, CD44 in Cutaneous Malignant Tumors

Affiliations
  • 1Department of Dermatology, College of Medicine, Soonchunhyang University, Seoul, Korea. MKCho2001@yahoo.co.kr
  • 2Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University, Seoul, Korea.

Abstract

BACKGROUND: Based on the unlimited proliferative and self-renewel properties of cancer cells similar to those of stem cells, the idea that cancer may originate from stem cells has been suggested in many different studies and has given rise to cancer stem cell hypothesis. CD133, being normally expressed on the surface of hematopoietic stem cells, has recently been suggested as a marker of cancer stem cells in several malignancies. CD24 and CD44 are membrane proteins reported as markers of various neoplasms.
OBJECTIVE
This study was designed to investigate the immunohistochemical expression of the CD24, CD44 and CD133 in squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and malignant melanoma (MM).
METHODS
We performed immunohistochemical staining for CD24, CD44 and CD133 using 18 skin cancer tissue samples, including 6 SCCs, 6 BCCs and 6 MMs. The expression of each marker was standardized by the histochemical score (HSCORE).
RESULTS
The expression of CD24 showed positive in 1 case of 6 SCCs (mean HSCORE, H; 0.02) and showed negative in 6 BCCs (H; 0.00), 6 MMs (H; 0.00). The expression of CD44 was not observed in 6 SCCs (H; 0.00) but observed in 1 case of 6 BCCs (H; 0.04) and 1 case of 6 MMs (H; 0.03). The expression of CD133 showed positive in 2 cases of 6 SCCs (H; 1.21) and 1 case of 6 BCCs (H; 0.05) and 6 cases of 6 MMs (H; 2.78).
CONCLUSION
Our data suggest that CD133 may be a reliable marker of which the higher expression is observed in the more invasive skin cancers and that the existence of cancer stem cells may enhance tumorigenic potential in cutaneous malignant tumors.

Keyword

Basal cell carcinoma; CD133; Malignant melanoma; Squamous cell carcinoma

MeSH Terms

Carcinoma, Basal Cell
Carcinoma, Squamous Cell
Hematopoietic Stem Cells
Melanoma
Membrane Proteins
Neoplastic Stem Cells
Skin Neoplasms
Stem Cells
Membrane Proteins
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