Korean J Dermatol.  2009 Mar;47(3):343-346.

A Case of Recalcitrant Pyoderma Gangrenosum Treated by Infliximab

Affiliations
  • 1Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea. dockbs@knu.ac.kr

Abstract

Pyoderma gangrenosum is an uncommon, neutrophilic, ulcerating, chronic dermatosis with obscure etiology. Many therapeutic modalities have been used in the past, but they have not always provided favorable outcomes. Recently, tumor necrosis factor-alpha inhibitors have been gaining attention in the treatment of recalcitrant pyoderma gangrenosum. A 57-year-old woman presented with painful, recurrent erythematous nodules and ulcers on both legs. She had been treated with systemic steroids, immunosuppressants, dapsone, and colchicine, and she experienced improvement with systemic steroids only. After using infliximab (5 mg/kg), she experienced dramatic improvement in her lesions. Thus, we report a recalcitrant case of pyoderma gangrenosum that was successfully treated with infliximab.

Keyword

Infliximab; Pyoderma gangrenosum

MeSH Terms

Antibodies, Monoclonal
Colchicine
Dapsone
Female
Humans
Immunosuppressive Agents
Leg
Middle Aged
Neutrophils
Pyoderma
Pyoderma Gangrenosum
Skin Diseases
Steroids
Tumor Necrosis Factor-alpha
Ulcer
Infliximab
Antibodies, Monoclonal
Colchicine
Dapsone
Immunosuppressive Agents
Steroids
Tumor Necrosis Factor-alpha
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