Korean J Dermatol.  2013 Dec;51(12):956-959.

Clinical Value of Hepatitis Screening and Liver Function Test in Korean Patients with Lichen Planus

Affiliations
  • 1Department of Dermatology, Korea University College of Medicine, Seoul, Korea. kumcihk@korea.ac.kr

Abstract

BACKGROUND
The relationship between viral hepatitis and lichen planus (LP) remains as a matter of controversy. Geographical variations are suggested to be a major factor influencing such association. Reliable figures from Korean patients are still lacking.
OBJECTIVE
The aim of this study is to determine the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in Korean patients with lichen planus (LP) and to compare it with patients without LP.
METHODS
The retrospective study was performed on 45 LP patients and 45 controls with matching age and gender. We examined for serological evidences of hepatic disease, hepatitis B surface antigen (HBsAg), and anti-HCV seropositivity. Statistical analysis was calculated by using an unpaired t-test and Fisher's exact test.
RESULTS
No significant differences between the serum levels of alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were observed between the two groups. The prevalence of HBsAg in LP patients (4.4%) was not significantly higher (p>0.05) than those of the control subjects (2.2%). None of the patients with LP nor the control subjects had Anti-HCV.
CONCLUSION
Korean patients with LP did not have any significant associations with liver diseases or HBV, and HCV infections. Although a large-scale multicenter study is needed to support our results, it is not advisable for Korean patients with LP to be tested for liver functions or HBV, and HCV infections as part of a routine screening test.

Keyword

Hepatitis; Korean; Lichen planus; Liver function

MeSH Terms

Alanine Transaminase
Aspartate Aminotransferases
Hepacivirus
Hepatitis B Surface Antigens
Hepatitis B virus
Hepatitis*
Humans
Lichen Planus*
Lichens*
Liver Diseases
Liver Function Tests*
Liver*
Mass Screening*
Prevalence
Retrospective Studies
Alanine Transaminase
Aspartate Aminotransferases
Hepatitis B Surface Antigens
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