Korean J Dermatol.  2015 Sep;53(8):631-634.

A Case of Autoimmune Progesterone Dermatitis Presenting as Erythema Multiforme

• Sung NH
• Kim TH
• Kim DH
• Shin H
• Lee AY
• Lee SH

Abstract

Autoimmune progesterone dermatitis is a rare disorder involving hypersensitivity to progesterone. It is most frequently characterized by recurrent erythema multiforme, eczematous or urticarial eruptions during the luteal phase of the menstrual cycle. It resolves or partially improves after menstruation. Sensitivity is demonstrated by a challenge test with medroxyprogesterone acetate. The therapeutic goal for autoimmune progesterone dermatitis is the suppression of ovulation. Currently, the first-line choice of therapy is a combination oral contraceptive. Here, we report a case of autoimmune progesterone dermatitis that manifested as cyclic bullous erythema multiforme. A reactive intradermal progesterone test confirmed the diagnosis.

Keyword

Autoimmune progesterone dermatitis; Erythema multiforme

MeSH Terms

Dermatitis*
Diagnosis
Erythema Multiforme*
Erythema*
Female
Hypersensitivity
Luteal Phase
Medroxyprogesterone Acetate
Menstrual Cycle
Menstruation
Ovulation
Progesterone*
Medroxyprogesterone Acetate
Progesterone