Korean J Dermatol.  2016 Jan;54(1):56-61.

Two Cases of Cutaneous Squamous Cell Carcinoma with Intracranial Extension

• Lee JM
• Shin JJ
• Jang HW
• Yoo MG
• Seo SH
• Kim IH

Abstract

Cutaneous squamous cell carcinoma (SCC) is the second most common skin malignant neoplasm. Cutaneous SCC shows a broad spectrum, ranging from easily managed superficial tumors to highly infiltrative, metastasizing ones that can cause death. We have experienced two patients with SCC with intracranial extension. One case was an 88-year-old man with a tumor on the forehead treated with Mohs micrographic surgery who presented with local recurrence at the perilesional region of the primary site after 3 years. Wide excision was performed, and histologic findings showed a SCC that extended to the dura mater. The other case was a 69-year-old woman who presented with an erythematous 2x4 cm-sized plaque on the right temple, and a biopsy examination revealed SCC. The patient refused surgery and 7 months later, presented with a 5x10 cm-sized oozing plaque with multiple ulcers. Radiologic evaluation demonstrated intracranial invasion and right retropharyngeal metastatic lymph nodes. She was treated with radiotherapy for 4 months.

Keyword

Cutaneous squamous cell carcinoma; Intracranial extension; Local recurrence; Metastasis; Mohs micrographic surgery

MeSH Terms

Aged
Aged, 80 and over
Biopsy
Carcinoma, Squamous Cell*
Dura Mater
Female
Forehead
Humans
Lymph Nodes
Mohs Surgery
Neoplasm Metastasis
Radiotherapy
Recurrence
Skin
Ulcer