Korean J Dermatol.  2016 Jan;54(1):47-51.

Two Cases of Bortezomib-induced Drug Eruption Presenting as Multiple Plaques on the Trunk

• Choe YS
• Kim EJ
• Na JI

Abstract

Bortezomib (Velcade(R)) is proteasome inhibitor that is used as a first-line therapy for multiple myeloma. It can cause gastrointestinal, hematologic, and neuromuscular side effects, and a cutaneous reaction is one of its common adverse reactions. To date, several bortezomib-induced cutaneous adverse reactions have been reported, including folliculitis-like rash, pruriginous rash, purpuric rash, mouth swelling, stomatitis-mucositis, edema in the lower limbs, telogen effluvium, and vasculitis. In the Korean literature, only one case of vasculitis has been reported earlier. Two patients have presented with multiple plaques on the trunk at our clinic. The lesions developed several days after bortezomib chemotherapy, and disappeared spontaneously in about 1 week. Herein, we report bortezomib-induced drug eruption presenting as multiple plaques on the trunk with a review of the relevant literature.

Keyword

Bortezomib; Drug eruption

MeSH Terms

Drug Eruptions*
Drug Therapy
Edema
Exanthema
Humans
Lower Extremity
Mouth
Multiple Myeloma
Proteasome Inhibitors
Vasculitis
Bortezomib
Proteasome Inhibitors