Survival rate of hepatectomy according to liver cirrhosis in hepatoculluar carcinoma

Lee, Chung Han; Shin, Dong Hoon; Park, Yong Jin; Yoon, Mung Hi; Choi, Kyung Hyen; Lee, Sung Do; Park, Young Hoon

Abstract

The authors analyzes the outcomes of patients with hepatocellular carcinoma and liver cirrhosis who underwent liver resection. Hepatic resection were carried out in 145 patients with hepatocellular carcinoma during 8-year period from 1990 to 1997. Of 145 hepatocellular carcinoma, one group of hepatocellular carcinoma with cirrhosis is 112(77.2%) cases, the other group of hepatocellular carcinoma without cirrhosis is 33(22.8%)cases. The serum HbsAg positivity is 80%(88/110) in hepatocellular carcinoma with cirrhosis, 63.6%(21/33) in hepatocellular carcinoma without cirrhosis. The serum Anti HCV positivity is 21.3%(20/94)in hepatocellular carcinoma with cirrhosis, 34.4%(10/29) in hepatocellular carcinoma without cirrhosis. According to liver resection, major resection is the right lobectomy, left lobectomy, extended right lobectomy, and extended left lobectomy, and minor resection is left lateral segmentectomy, segmentectomy, subsegmentectomy The survival rate and postoperative complications were compared hepatocellular carcinoma with cirrhosis with hepatocellular carcinoma without cirrhosis. The survival rate of 1 year, 2 year , 3 year and 5 year was 63%, 47%, 36% and 25% in hepatocellular carcinoma with cirrhosis and 63%, 56%, 48% and 39% in hepatocellular carcinoma without cirrhosis. The group without liver cirrhosis is somewhat higher in survival rate, but the outcome was not statistically significant.(p>0.05). Overall operative mortality was 4.1%(6/145), With liver cirrhosis 5,4%(6/112) in group. Of this 6 cases , four cases were hepatic failure, two cases postoperative bleeding. Group without liver cirrhosis had not mortality cases. Of the group combined with liver cirrhosis, the operative mortality for operation method was 13%(3/23) in major resection group, 3.4%(3/89) in minor resection group.