Korean J Gastrointest Endosc.  2006 Apr;32(4):283-286.

A Case of Multiple Cystic Brunner's Gland Hyperplasia

• Maeng CH
• Jang JY
• Joo KR
• Dong SH
• Kim HJ
• Kim BH
• Chang YW
• Lee JI
• Chang R
• Kim YW

Abstract

Hyperplasia of Brunner's glands is considered an uncommon finding; its wide range of morphological variation has led to confusing identifying terminology which includes: hyperplasia, adenoma, and hamartoma. Some investigators have suggested that hyperplasia of Brunner's glands is hamartomatous in nature, whereas others have favored a causative relationship that results from gastric acid hypersecretion. Although most commonly an incidental finding, that appears as multiple small submucosal sessile nodules, usually located in the duodenal bulb, it can lead to clinically significant symptoms including gastrointestinal bleeding, abdominal pain, and intestinal obstruction. Here, we report a case of hyperplasia of multiple cystic Brunner's glands on the duodenal bulb in a patient with acute pancreatitis; they were discovered incidentally on abdominal CT and duodenoscopy. This is the first report of hyperplasia of Brunner's glands with these morphological characteristics.

Keyword

Brunner's glands; Hyperplasia; Multiple; Cystic

MeSH Terms

Abdominal Pain
Adenoma
Brunner Glands
Duodenoscopy
Gastric Acid
Hamartoma
Hemorrhage
Humans
Hyperplasia*
Incidental Findings
Intestinal Obstruction
Pancreatitis
Research Personnel
Tomography, X-Ray Computed