Korean J Gastrointest Endosc.  2006 Apr;32(4):278-282.

A Case of Duodenal Obstruction Induced by the Short-term Use of a Nonsteroidal Anti-inflammatory Drug

• Song JH
• Shim KN
• Song HJ
• Oh HJ
• Ryu KH
• Yeom HJ
• Kim SE
• Kim TH
• Jung HK
• Jung SA
• Yoo K
• Moon IH

Abstract

Giant duodenal ulcer can be defined as a variant of peptic ulceration that exceeds 2 cm at the greatest diameter. The high mortality and morbidity of giant duodenal ulcer are directly related to the resultant perforation, obstruction and massive hemorrhage. The patient usually has a long history of an inadequately treated or neglected peptic ulcer, but this malady is rarely induced by nonsteroidal anti-inflammatory drugs (NSAIDs). A 60-year-old man was referred to us due to epigastric pain. He underwent appendectomy 1 week ago, and he was administered ketorolac (tarasyn(R)) for 5 days to control the postoperative pain. Esophagogastroduodenos copy (EGD) revealed a giant duodenal ulcer encircling the lumen from the pylorus to the postbulbar portion of the duodenum, and he was then treated with proton pump inhibitor. Two weeks later, the follow-up EGD showed complete duodenal obstruction at the bulb. He was treated by laparoscopic gastrojejunostomy. We report here on this case of duodenal obstruction that was induced by the short-term use of NSAIDs.

Keyword

NSAIDs; Duodenal obstruction

MeSH Terms

Anti-Inflammatory Agents, Non-Steroidal
Appendectomy
Duodenal Obstruction*
Duodenal Ulcer
Duodenum
Follow-Up Studies
Gastric Bypass
Hemorrhage
Humans
Ketorolac
Middle Aged
Mortality
Pain, Postoperative
Peptic Ulcer
Proton Pumps
Pylorus
Anti-Inflammatory Agents, Non-Steroidal
Ketorolac
Proton Pumps