Korean J Gastrointest Endosc.
1998 Dec;18(6):847-852.
Metronidazole Resistance and the Eradication of Helicobacter pylori
- Affiliations
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- 1Department of Internal Medicine, Hanyang University College of Medicine.
- 2Clinical Pathology, Hanyang University Kuri Hospital, Seoul, Korea.
Abstract
- BACKGROUND/AIMS
The success of Helicobacter pylori eradication is limited by antibiotic resistances, and the primary resistance to metranidazole seems to be high. In this study, the frequency af metronidazole resistance and the eradication rate in metronidazole-resistant H. pylori strain was evaluated.
METHODS
Sixty-eight patients were tested for metronidazole resistance using microdilution broth, the E test and disk diffusion method. Twenty-two patients were treated for 14 days with amoxicilline 2000 mg, metronidazole 750 mg, and tripotassium dicitrate bismuth 1200 mg.
RESULTS
Metronida-zole resistance was 46% (31/68). The eradication rates for H. pylori was 91.7% in patients with metronidazole-sensistive strains and 70% in patients with metronidazole-resistant strains.
CONCLUSIONS
Metronidazole resistance was high (46%) in Korea, however, triple therapy was an efficient method of eradicating H. pylori in both metronidazole sensitive and resistant strains.
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