Korean J Gastrointest Endosc.  2002 Jan;24(1):6-10.

Endoscopic Findings of Newly Developed Gastrointestinal Lesions after Eradication for Helicobacter pylori

• Hong SJ
• Ko BM
• Kim JO
• Cho JY
• Lee JS
• Lee MS
• Shim CS

Abstract

BACKGROUND/AIMS: Eradication therapy for H. pylori infection is routinely used for treating patients with peptic ulcer disease. However, endoscopic findings after eradication therapy reveal some newly developed lesions. We have reviewed endoscopic findings to evaluate frequency and morphology of upper gastrointestinal lesions after eradication therapy for H. pylori.
METHODS
We have studied 245 patients with peptic ulcer disease and H. pylori infection who had a successful eradication therapy. Endoscopic evaluation with rapid urease test, histology, and 13C-urea breath test was performed before eradication therapy and 6 weeks after.
RESULTS
The incidence of newly developed lesions after eradication therapy was 14.3% at 6 weeks. The features of newly developed lesions after eradication therapy were as follows: 7 with reflux esophagitis (2.9%), 10 with acute gastritis (4.1%), 3 with duodenal ulcers (1.2%), 15 with erosive duodenitis (6.1%). These lesions were found during administration of H2 receptor blocker. No additional symptoms were found in these mucosal lesions. The development of these lesions was not related to duration of antibiotics.
CONCLUSIONS
It is not rare to find some newly developed lesions after treatment of H. pylori infection. It is necessary to study pathogenesis of these lesions and have follow-up endoscopic examinations for a longer period of time.

Keyword

Newly developed lesions; H. pylori; Eradication

MeSH Terms

Anti-Bacterial Agents
Breath Tests
Duodenal Ulcer
Duodenitis
Esophagitis, Peptic
Follow-Up Studies
Gastritis
Helicobacter pylori*
Helicobacter*
Humans
Incidence
Peptic Ulcer
Urease
Anti-Bacterial Agents
Urease