Korean J Hepatobiliary Pancreat Surg.  2013 Feb;17(1):38-41. 10.14701/kjhbps.2013.17.1.38.

A case of primary adenosquamous carcinoma of the liver

  • 1Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. gie001@cnuh.co.kr
  • 2Department of Pathology, Chungnam National University School of Medicine, Daejeon, Korea.


Adenosquamous carcinoma (ASC) is a rare tumor of the liver, which carries a poor prognosis. It has been reported mostly in the form of case studies. Recently, we experienced a case of primary ASC of the liver that has been preoperatively considered as cholangiocelluar carcinoma of the liver. Microscopically, the tumor was composed of adenocarcinoma, squamous cell carcinoma, as well as transitional area, including the transformation of adenocarcinoma to squamous cell carcinoma. The patient remained well with no evidence of post-resection complication or recurrence for 15 month.


Cholangiocelluar carcinoma; Adenosquamous carcinoma; Liver

MeSH Terms

Carcinoma, Adenosquamous
Carcinoma, Squamous Cell


  • Fig. 1 Abdomen computed tomography shows a hypo-dense mass with irregular margin on the left hemiliver with early rim enhancement in the arterial phase (A) and slow central enhancement on delayed image (B).

  • Fig. 2 Microscopic findings of tumors (A) Adenocarcinoma transformed to squamous cell carcinoma compoment (arrow); (B) Adenocarcinoma (the left side of the specimen: black arrow) combined with squamous cell carcinoma (the right side of the specimen: white arrow) (C) Adenosquamous transformation area (arrow) (H&E, ×100).


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