J Bone Metab.  2014 May;21(2):133-141. 10.11005/jbm.2014.21.2.133.

Association of Arterial Stiffness and Osteoporosis in Healthy Men Undergoing Screening Medical Examination

• Kim NL
• Jang HM
• Kim SK
• Ko KD
• Hwang IC
• Suh HS

• KMID: 2241534
• DOI: http://doi.org/10.11005/jbm.2014.21.2.133

Abstract

BACKGROUND
Association of arterial stiffness and osteoporosis has been previously reported in women. However, this association is still controversial for men. Therefore, we investigated correlation of arterial stiffness and osteoporosis by measuring brachial-ankle (ba) pulse wave velocity (PWV) and bone mineral density (BMD).
METHODS
We reviewed medical charts of 239 people (women: 128, men: 111) who visited the Health Promotion Center, retrospectively. ba-PWV was measured by automatic wave analyzer. Lumbar spine (L1-L4) BMD and femur BMD were measured by dual energy X-ray absorptiometry. Metabolic syndrome was based on the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATPIII) definition. Body mass index (BMI)>25 kg/m2 was used instead of waist circumference.
RESULTS
In Pearson's correlation analysis, PWV and femur BMD (Neck, total) had a significant inverse relationship in men (r=-0.254, P=0.007; r=-0.202, P=0.034). In women, PWV and the L-spine, femur (Neck, total) had a significant inverse relationship. (r=-0.321, P<0.001; r=-0.189, P=0.032; r=-0.177, P=0.046) Age and PWV showed the greatest association in both men and women (r=0.46 P<0.001; r=0.525, P<0.001) In multiple regression analysis, the L-spine BMD and PWV had an independent relationship in women after adjusting for age, metabolic syndrome, BMI, smoking, drinking and exercise. (r=-0.229, P=0.015). No independent association was found between PWV and BMD in men.
CONCLUSIONS
The association between arterial stiffness and BMD was confirmed in women. However, this association was not statistically significant for men.

Keyword

Bone density; Osteoporosis; Pulse wave analysis; Vascular stiffness

MeSH Terms

Absorptiometry, Photon
Body Mass Index
Bone Density
Cholesterol
Drinking
Education
Female
Femur
Health Promotion
Humans
Male
Mass Screening*
Osteoporosis*
Pulse Wave Analysis
Retrospective Studies
Smoke
Smoking
Spine
Vascular Stiffness*
Waist Circumference
Cholesterol
Smoke

Figure

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  Fig. 1 (A) Correlation between lumbar spine bone mineral density (BMD) and age (scatter plot). (B) Correlation between femur BMD and age (scatter plot).

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  Fig. 2 (A) Correlation between lumbar spine bone mineral density (BMD) and pulse wave velocity (PWV) (scatter plot). (B) Correlation between femur BMD and PWV (scatter plot).

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