Korean J Gastroenterol.  2002 Aug;40(2):126-132.

Relationship among Fat, Protein, and Carbohydrate Absorptions in Canine Exocrine Pancreatic Insufficiency

• Chung JP
• Chung JB
• Park SW
• Lee SJ
• Moon BS
• Song SY
• Lee KS
• Lee SI
• Moon YM
• Kang JK
• DiMagno EP

Abstract

BACKGROUND/AIMS: Interactions among fat, protein, and carbohydrate absorption may play a role in the treatment of steatorrhea. We determined in canine exocrine pancreatic insufficiency (EPI) whether fat, protein, and carbohydrate absorptions are dependent on the pancreatic enzyme preparation (bacterial lipase, BL; porcine lipase, PL) and whether absorption of fat is related to absorptions of protein and carbohydrate.
METHODS
Five dogs underwent ligation of pancreatic ducts. Then, seventy two-hour fecal balance studies were performed while a high fat meal (fat 43%) was given. Powdered BL or PL was given at doses of 0, 7,500, 15,000, and 30,000 IU. Stool fat, protein, and carbohydrate were measured and coefficients of fat (CFA), protein (CPA), and carbohydrate (CCA) absorptions were calculated. Multiple regression analysis was used for statistical analysis.
RESULTS
CFA and CPA increased preparation (PL is better than BL) and dose dependently. However, CCA increased dose-dependently but not preparation-dependently. Fat absorption increased as protein and carbohydrate absorption increased (p<0.001).
CONCLUSIONS
In dogs with EPI fed a high fat diet, porcine pancreatic enzyme increases fat and protein absorption greater than bacterial lipase, and the increase of fat absorption is related to the increase of protein and carbohydrate absorptions.

Keyword

Exocrine pancreatic insufficiency; Fats; Proteins; Carbohydrates; Absorption

MeSH Terms

Absorption*
Animals
Carbohydrates
Diet, High-Fat
Dogs
Exocrine Pancreatic Insufficiency*
Fats
Ligation
Lipase
Meals
Pancreatic Ducts
Regression Analysis
Steatorrhea
Carbohydrates
Fats
Lipase