Korean J Lab Med.  2005 Feb;25(1):24-27.

A Case of Hodgkin`s Lymphoma with Bone Marrow Involvement Showing Severe Osteosclerosis

  • 1Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea. m91w95@dreamwiz.com
  • 2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.


Bone marrow involvement in Hodgkin`s lymphoma is not rare at initial diagnosis and is associated with a poor prognosis. Atypical findings such as granuloma, eosinophilia or osteosclerosis may lead to diagnostic confusion, in which case immunohistochemistry may be helpful. We report a case of 25-year old male patient, who presented with back pain, subsequently had a mediastinal mass and was finally diagnosed as having stage IV Hodgkin`s lymphoma. Bone marrow involvement with severe osteosclerosis was found on bone marrow biopsy specimens. He received systemic chemotherapy and was discharged with improved clinical symptoms.


Osteosclerosis; Hodgkin`s lymphoma; Bone marrow involvement
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