Korean J Community Nutr.  2008 Feb;13(1):91-99.

Relationship between Ferric Reducing Antioxidant Power and Metabolic Risk Factors in Korean Women Living in Seoul

Affiliations
  • 1Department of Home Economics, Korea National Open University, Seoul, Korea.
  • 2CoreMed Co. Ltd., Healthcare Company, Seoul, Korea.
  • 3Department of Food and Nutrition, Yonsei University, Seoul, Korea. snkim@yonsei.ac.kr

Abstract

The present study was conducted to examine metabolic risk factors and total antioxidant capacity (TAC) of Korean females living in Seoul and to investigate the relationship between the metabolic risk factors and serum TAC. A total of 353 females aged between 20 and 64 participated in the study. Obesity indicators, blood pressure, serum lipid profile and fasting blood glucose were measured as metabolic risk factors. Ferric reducing antioxidant power (FRAP) assay was employed to determine serum TAC of subjects. Obesity indicators such as body mass index, waist circumference and waist-hip ratio were significantly higher in the participants aged > or = 50 y (older group) than in the participants aged 20-49 y (younger group) (p < 0.001). Blood pressure, serum total cholesterol (TC), riglyceride (TG) and fasting blood glucose were also significantly higher in the older group than in the younger group (p < 0.001), demonstrating significant positive correlations between age and MS risk factors. The association between FRAP and MS risk factors were also investigated. FRAP values showed significant positive correlations with age (p = 0.001), serum TG (p = 0.002) and TC (p = 0.03). A tendency of positive association between FRAP and waist circumference was observed without any significant difference (p = 0.06). Increased serum FRAP with central obesity and serum lipids may be interpreted as results of activation of antioxidant defense system against oxidative stress induced by metabolic syndrome (MS) constituent factors. However, to verify the function of FRAP as a potential biomarker of susceptibility to MS various contributors to the plasma antioxidant capacity and their biological relevance related to MS should be elucidated further.

Keyword

ferric reducing antioxidant power; metabolic syndrome; obesity; cholesterol; triglyceride

MeSH Terms

Aged
Blood Glucose
Blood Pressure
Body Mass Index
Cholesterol
Fasting
Female
Humans
Obesity
Obesity, Abdominal
Oxidative Stress
Plasma
Risk Factors
Waist Circumference
Waist-Hip Ratio
Blood Glucose
Cholesterol
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