Korean J Anesthesiol.  2008 Oct;55(4):473-478. 10.4097/kjae.2008.55.4.473.

Ketamine potentiates neurotoxicity in obese mice

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. pauly@catholic.ac.kr

Abstract

BACKGROUND: Obesity exacerbates chemically-induced neurodegeneration. N-methyl-D-aspartate (NMDA) antagonists such as ketamine prevent excitotoxicity and are neuroprotective against acute brain injury, but can also be toxic. In low doses they induce reversible neuronal injury, but in higher doses they cause irreversible degeneration of cerebrocortical neurons. This study was designed to evaluate the neurotoxic effect of ketamine on obesity-induced neurotoxicity in the young mouse brain.
METHODS
Five-week-old female wild and obese type (C57BL6) mice were randomly allocated into three groups (n=6 each) receiving a single intraperitoneal injection of (i) saline (control); (ii) ketamine (50 mg/kg); (iii) or ketamine (100 mg/kg). Three hours after ketamine administration, their brains were prepared histologically for quantitative assessment of the number of posterior cingulate/retrosplenial (PC/RS) neurons with vacuolation at a specific rostrocaudal level.
RESULTS
Pyramidal neurons containing cytoplasmic vacuoles in layers III and IV of the PC/RS cortex were observed in all groups of mice, except wild-type mice that received saline injections. Ketamine produced a dose-dependent vacuolization in both types of mice, which was more prominent in obese mice (P < 0.05).
CONCLUSIONS
Administration of ketamine in young obese mice can exacerbate neurotoxicity.

Keyword

cingulated cortex; ketamine; mouse; neurotoxicity; obesity

MeSH Terms

Animals
Brain
Brain Injuries
Cytoplasm
Female
Humans
Injections, Intraperitoneal
Ketamine
Mice
Mice, Obese
N-Methylaspartate
Neurons
Obesity
Vacuoles
Ketamine
N-Methylaspartate
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