Korean J Anesthesiol.  2007 Oct;53(4):497-503. 10.4097/kjae.2007.53.4.497.

Comparison of the Antiallodynic Effects of Intrathecal Lidocaine and MK-801 on Mechanical Allodynia in Two Neuropathic Pain Rat Models

Affiliations
  • 1Department of Anesthesiology and Pain Medicaine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea. jhhwang@amc.seoul.kr

Abstract

BACKGROUND: Neuropathic pain can be induced by nerve injury or inflammation. An N-methyl-D-Aspartate (NMDA) antagonist (MK-801), and a sodium channel blocker (lidocaine) have been found to reduce mechanical allodynia. This study was conducted to determine whether intrathecal lidocaine or MK-801 had an antiallodynic effect on established mechanical allodynia in two well-characterized neuropathic pain rat models.
METHODS
Male Sprague Dawley rats (n = 107) were anesthetized, and the left L5 and L6 spinal nerves were ligated (SNL group) or Freund complete adjuvant (FCA) was administrated to the same spinal nerves (FCA group) in order to cause neuropathic pain. A catheter was then implanted into the lumbar intrathecal space. After obtaining the baseline scores, time-effect curves of each drug were established for the antiallodynic effects of lidocaine (30g, 100g and 300g) and MK-801 (1g, 3g, 10g and 30g). The allodynic thresholds for the left hind paw withdrawal to von Frey hairs were assessed and converted to %MPE, and the ED50 value was then calculated using the %MPE. The antiallodynic effects of the two groups were then compared by analyzing the dose-response curves and the ED50 values.
RESULTS
Both intrathecal lidocaine and MK-801 resulted in a dose dependent antiallodynic effect. ED50 values and the analysis of dose response curves showed that intrathecal lidocaine provided more effective antiallodynia in the SNL group, whereas intrathecal MK-801 resulted in a greater antiallodynic effect in the FCA group.
CONCLUSIONS
In the SNL group, lidocaine had a better effect in reducing allodynic pain, whereas in the FCA group, MK-801 showed a greater antiallodynic effect.

Keyword

allodynia; FCA; intrathecal administration; lidocaine; MK-801; spinal nerve ligation

MeSH Terms

Animals
Catheters
Dizocilpine Maleate*
Hair
Humans
Hyperalgesia*
Inflammation
Lidocaine*
Male
Models, Animal*
N-Methylaspartate
Neuralgia*
Rats*
Rats, Sprague-Dawley
Sodium Channels
Spinal Nerves
Dizocilpine Maleate
Lidocaine
N-Methylaspartate
Sodium Channels
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