Int Neurourol J.  2014 Sep;18(3):106-114. 10.5213/inj.2014.18.3.106.

Metabolomics Insights Into Pathophysiological Mechanisms of Interstitial Cystitis

Affiliations
  • 1West Coast Metabolomics Center, University of California, Davis, Davis, CA, USA.
  • 2King Abdulaziz University, Jeddah, Saudi Arabia.
  • 3Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Jayoung.Kim@cshs.org
  • 4Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • 5The Urological Diseases Research Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Abstract

Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.

Keyword

Interstitial cystitis; Metabolomics; Biological markers; Magnetic resonance spectroscopy; Mass spectrometry

MeSH Terms

Bacterial Infections
Biomarkers
Cystitis, Interstitial*
Dermatoglyphics
Early Diagnosis
Magnetic Resonance Spectroscopy
Mass Spectrometry
Metabolome
Metabolomics*
Pelvic Pain
Quality of Life
Urinary Bladder
Urinary Tract
Full Text Links
  • INJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr