Korean Circ J.  1998 Jul;28(7):1105-1111. 10.4070/kcj.1998.28.7.1105.

4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Its Effects on Coronary Artery Disease

• Kang HJ
• Han KH
• Choe SC
• Kim HS
• Sohn DW
• Oh BH
• Lee MM
• Park YB
• Choi YS
• Lee YW

• KMID: 2228858
• DOI: http://doi.org/10.4070/kcj.1998.28.7.1105

Abstract

BACKGROUND
4G allele of one base pair insertion/deletion polymorphism (4G/5G) at plasminogen activator inhibitor-1 (PAI-1) was associated with increased plasma activity of PAI-1. Increased plasma PAI-1 activity was associated with increase risk of coronary artery disease (CAD). However, there was a controversy whether 4G allele increases the risk of CAD. We investigated relationship between 4G/5G genetic polymorphism and CAD in Korean population.
METHODS
We studied 453 patients-145 patients with normal coronary angiogram (NL), 106 with stable angina (SA), 104 with unstable angina (UA) and 98 with myocardial infarction (MI)-characterized by coronary angiography.
RESULTS
1) Korean had higher 4G allele frequency than Caucasian (4G:5G=0.60:0.40 in Korean). 2) There were no allele or gene frequency difference of 4G/5G polymorphism between CAD group and NL group (4G:5G=0.61:0.39 in CAD, 0.59:0.41 in NL, p=0.58). 3) 4G allele was not associated with increased risk of acute coronary syndrome (4G:5G=0.60:0.40 in SA, 0.59:0.41 in UA, and 0.57:0.43 in MI, p=0.84). 4) 4G allele had no influence on progression of coronary artherosclerosis (4G:5G=0.58:0.42 in single vessel disease, 0.58:0.42 in two vessel disease, and 0.56:0.44 in three vessel disease, p=0.82). 5) 4G was not an independent risk factor of CAD even after adjusted with other risk factors.
CONCLUSION
In Korean, 4G/5G polymorphism of PAI-1 gene has no relationship with development, progression of coronary artery disease.

Keyword

Plasminogen activator inhibitor-1; 4G/5G polymorphism; Coronary artery disease

MeSH Terms

Acute Coronary Syndrome
Alleles
Angina, Stable
Angina, Unstable
Base Pairing
Coronary Angiography
Coronary Artery Disease*
Coronary Vessels*
Gene Frequency
Humans
Myocardial Infarction
Plasma
Plasminogen Activator Inhibitor 1
Plasminogen Activators*
Plasminogen*
Polymorphism, Genetic
Risk Factors
Plasminogen
Plasminogen Activator Inhibitor 1
Plasminogen Activators