Korean Circ J.  2001 Apr;31(4):398-404. 10.4070/kcj.2001.31.4.398.

Meaning of serum antibody to Chlamydia pneumoniae in patients with restenosis after coronary balloon angioplasty or stent insertion

• Seong IW

• KMID: 2227303
• DOI: http://doi.org/10.4070/kcj.2001.31.4.398

Abstract

BACKGROUND: The relationship between infection of Chlamydia pneumoniae and atherosclerotic disease such as coronary artery disease has been studied because many epidemiologic studies using antibody detection reported positive correlation between them. But there are controversies in the role of Chlamydia pneumoniae to restenosis after angioplasty or stent insertion. This study was purposed on the prevalence of Chlamydia infection in the patients with restenosis after percutaneous coronary intervention (PCI) and the possible role of Chlamydia to restenosis in Korea.
METHODS
Total 110 subjects were enrolled and age and sex adjusted subjects were divided into 4 groups, angioplasty-no restenosis group (n=2), angioplasty-restenosis group (n=0), stent-no restenosis group (n=2), stent-restenosis group (n=6). Serum total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C) were measured, LDL-cholesterol (LDL-C) was calculated. Serum anti-Chlamydia pneumoniae IgG were measured by ELISA method.
RESULTS
There was no significant differences in clinial and lipid profiles between restenosis and non-restenosis groups regardless of balloon angioplasty or stenting. There was no statistical significance in positivity of anti-Chlamydia pneumoniae IgG between restenosis and non-restenosis groups after any PCI.
CONCLUSION
This study could not demonstrate the relationship between Chlamydia infection and restenosis after angioplasty or stent insertion in Korea.

Keyword

Chlamydia pneumoniae antibody; angioplasty; stent; restenosis

MeSH Terms

Angioplasty
Angioplasty, Balloon
Angioplasty, Balloon, Coronary*
Chlamydia Infections
Chlamydia*
Chlamydophila pneumoniae*
Cholesterol
Coronary Artery Disease
Enzyme-Linked Immunosorbent Assay
Epidemiologic Studies
Humans
Immunoglobulin G
Korea
Percutaneous Coronary Intervention
Pneumonia
Prevalence
Stents*
Triglycerides
Cholesterol
Immunoglobulin G