Korean Circ J.  2004 Mar;34(3):265-270. 10.4070/kcj.2004.34.3.265.

The Effect of Systemic Inflammation on the Elevation of Troponin I after Percutaneous Transluminal Coronary Angioplasty with Stent in Patients with Stable Angina

• Kim YC
• Sung KC
• Park SH
• Kim BJ
• Kim BS
• Kang JH
• Lee MH
• Park JR
• Park HS
• Keum DK
• Ryu SH
• Beck SH

• KMID: 2227212
• DOI: http://doi.org/10.4070/kcj.2004.34.3.265

Abstract

BACKGROUND AND OBJECTIVES
There is growing evidence that inflammation plays an important role in atherosclerosis and in the elevation of cardiac troponin I (cTnI) after coronary intervention. The aim of this study was to evaluate the relationship between inflammatory markers and the elevation of cTnI after coronary intervention in patients with stable angina.
SUBJECTS AND METHODS
Twenty-three patients who underwent successful percutaneous transluminal coronary angioplasty with stent were examined as the subjects. Serial blood samples were obtained for High Sensitivity C-reactive protein (hs-CRP), which served as markers of systemic inflammation, and cTnI. The difference of cTnI before and 24 hours after coronary intervention was defined as the gradient of cTnI.
RESULTS
The mean gradient of cTnI was 1.77+/-3.4 ng/mL. The concentrations of baseline and post-procedural hs-CRP were 1.57+/-1.3 mg/L and 6.31+/-3.8 mg/L, respectively (p=0.001). There were no significant differences in the gradient of cTnI with hypertention, diabetes, smoking, and hypercholesterolemia. The variable that significantly correlated with the gradient of cTnI was the baseline hs-CRP (R2=0.374, p=0.048).
CONCLUSION
Systemic inflammation correlated with periprocedural elevation of cTnI in stable angina patients. These results suggest that inflammation plays a pivotal role in the predictive value of myocardial injury after coronary intervention.

Keyword

C-reactive protein (CRP); Troponin I; Angina pectoris; Stents

MeSH Terms

Angina Pectoris
Angina, Stable*
Angioplasty, Balloon, Coronary*
Atherosclerosis
C-Reactive Protein
Humans
Hypercholesterolemia
Inflammation*
Smoke
Smoking
Stents*
Troponin I*
Troponin*
C-Reactive Protein
Smoke
Troponin
Troponin I