Korean Circ J.  2008 May;38(5):237-243. 10.4070/kcj.2008.38.5.237.

Recent Update on Fixed Combinations of Antihypertensive Agents

Affiliations
  • 1Division of Cardiology, College of Medicine, Korea University, Seoul, Korea. kuhpark@yahoo.com; parkcg@kumc.or.kr

Abstract

The amlodipine/atorvastatin single tablet has been shown to improve patients' achievement of national guideline recommended blood pressure and lipid target levels and exhibits a safety profile consistent with the parent com-pounds. The single tablet formulation has the potential to improve adherence and decrease prescription costs. These potential benefits are associated with important implications because hypertensive patients with additional risk factors represent a large proportion of those at risk for cardiovascular events. Combination low-dose drug treatment increases efficacy and reduces adverse effects. Fixed low-dose combination drug treatment increases efficacy and reduces adverse effects. This combination has greater potency and a similar side effect profile to monotherapy and represents a highly effective approach for attaining goal blood pressure levels using a therapeutic strategy that very effectively lowers blood pressure, is well-tolerated, and minimizes increasing doses of monotherapy-induced metabolic effects.

Keyword

Combination drug therapy; Amlodipine; Atorvastatin; Risk reduction
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