J Rheum Dis.  2012 Jun;19(3):147-151. 10.4078/jrd.2012.19.3.147.

A Case of Intestinal Behcet's Disease Complicated Enterocutanous Fistula with a Good Response to Adalimumab

Affiliations
  • 1Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. wsuhm@hanyang.co.kr
  • 2Department of Rheumatology, Hanyang University Hospital for Rheumatic Disease, Seoul, Korea.

Abstract

Behcet's disease (BD) is a multisystemic disorder, which is characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesion. Although intestinal involvement is an uncommon manifestation of the BD, it leads to a poor prognosis, as a result of a high complication, such as intestinal perforation, fistula formation, and massive hemorrhage. Intestinal BD has the tendency for the resistance to conventional medical treatment, and it often requires a surgical intervention because of severe complication. Although the causes of intestinal BD are unknown, some studies show that tumor necrosis factor Alpha (TNF-alpha) plays a key role in the pathogenesis of BD. Therefore, anti-TNF-alpha monoclonal antibody, such as adalimumab, is one of the useful treatment for refractory and relapsed intestinal BD. We describe a patient who had intestinal BD complicated enterocutanous fistula with a good response to adalimumab.

Keyword

Behcet's disease; Intestine; TNF-alpha; Adalimumab
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