J Rheum Dis.  2012 Dec;19(6):341-343. 10.4078/jrd.2012.19.6.341.

Treatment with High Dose Dexamethasone of Severe Thrombocytopenia in Primary Sjogren's Syndrome

Affiliations
  • 1Department of Internal Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea. choisw@uuh.ulsan.kr

Abstract

Sjogren's syndrome is a systemic autoimmune disease characterized by sicca symptoms and B lymphocyte hyperactivity. Hematological abnormalities are common in Sjogren's syndrome, including anemia, leukopenia, thrombocytopenia, and lymphoproliferative disorders. These hematologic involvements are mostly recognized as mild laboratory abnormalities. Life-threatening, severe thrombocytopenia is very rare. We describe a patient with primary Sjogren's syndrome, who developed very severe thrombocytopenia during the clinical course and successfully treated with high dose dexamethasone therapy.

Keyword

Sjogren's syndrome; Thrombocytopenia; Purpura

MeSH Terms

Anemia
Autoimmune Diseases
Dexamethasone
Humans
Leukopenia
Lymphocytes
Lymphoproliferative Disorders
Purpura
Sjogren's Syndrome
Thrombocytopenia
Dexamethasone

Figure

  • Figure 1 Peripheral blood smear is notable for severe thrombocytopenia (H&E, ×400).

  • Figure 2 Bone marrow biopsy specimen shows adequate numbers of megakaryocytes without myelodysplasia or myelofibrosis (H&E, ×400).

  • Figure 3 Clinical course of this case. Platelet counts were increased significantly after dexamethasone pulse therapy.


Cited by  1 articles

A Case of Treatment with Steroid and Hydrochloroquine of Thrombocytopenia in Primary Sjögren's Syndrome
Yeong Seop Yun, Ji Wook Choi, Young Jae Doo, Tae Hyung Kim, Hye Lim Oh, Ji Min Oh
Kosin Med J. 2017;32(1):118-126.    doi: 10.7180/kmj.2017.32.1.118.


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