J Rheum Dis.  2012 Dec;19(6):341-343. 10.4078/jrd.2012.19.6.341.

Treatment with High Dose Dexamethasone of Severe Thrombocytopenia in Primary Sjogren's Syndrome

Affiliations
  • 1Department of Internal Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea. choisw@uuh.ulsan.kr

Abstract

Sjogren's syndrome is a systemic autoimmune disease characterized by sicca symptoms and B lymphocyte hyperactivity. Hematological abnormalities are common in Sjogren's syndrome, including anemia, leukopenia, thrombocytopenia, and lymphoproliferative disorders. These hematologic involvements are mostly recognized as mild laboratory abnormalities. Life-threatening, severe thrombocytopenia is very rare. We describe a patient with primary Sjogren's syndrome, who developed very severe thrombocytopenia during the clinical course and successfully treated with high dose dexamethasone therapy.

Keyword

Sjogren's syndrome; Thrombocytopenia; Purpura
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