J Rheum Dis.  2013 Oct;20(5):286-296. 10.4078/jrd.2013.20.5.286.

Application of Induced Pluripotent Stem Cells in Rheumatology

• Jung SM
• Ju JH

• KMID: 2223004
• DOI: http://doi.org/10.4078/jrd.2013.20.5.286

Abstract

Since induced pluripotent stem cell (iPSC) was first introduced by Yamanaka in 2006, it took only six years to win a Nobel Prize for his pioneering work. It is unusual to win a Nobel Prize for such recent research with a short history. Many scientists and clinicians are interested in iPSC for its potential application. Significant progression in this field has been made, while there remain many hurdles to overcome for application of iPSC technique in real clinics. In this review, the concept of reprogramming and the basic techniques of iPSC generation will be discussed for the reader's convenience, followed by discussion of recent progress, followed by the topics of "disease modeling" and "cell therapy" with iPSC in the second half of this article. Several examples of rheumatologic application of iPSC will be provided in the main text. If rheumatologists could understand the merits and potentials of iPSC, opportunities for innovative research and therapy can be expanded.

Keyword

Induced pluripotent stem cell; Rheumatoid arthritis; Osteoarthritis; Fibroblast like synoviocyte; Lentivirus; Reprogramming

MeSH Terms

Arthritis, Rheumatoid
Induced Pluripotent Stem Cells*
Lentivirus
Nobel Prize
Osteoarthritis
Pluripotent Stem Cells
Rheumatology*