J Rheum Dis.  2014 Aug;21(4):182-186. 10.4078/jrd.2014.21.4.182.

Human Leukocyte Antigen-DRB1 Associations in Korean Juvenile Rheumatoid Arthritis

• Lee CJ
• Sohn TY
• Lee DH
• Lee HR
• Kim M
• Kim KN

• KMID: 2222958
• DOI: http://doi.org/10.4078/jrd.2014.21.4.182

Abstract

OBJECTIVE
The aim of this study is to investigate the association of different subgroups of juvenile rheumatoid arthritis (JRA) with human leukocyte antigen (HLA) class II DR alleles.
METHODS
One hundred and nineteen Korean juvenile rheumatoid arthritis patients were classified as HLA-DRB1 allele. To assess the frequency, phenotype frequencies of all JRA cases and each subtypes were compared to those of 485 adult controls.
RESULTS
HLA-DRB1*01 was associated with increased risk of JRA. Furthermore, DRB1*01 was associated with polyarticular JRA and pauciarticular JRA. The frequencies of DRB1*14 and DRB1*15 were higher in systemic JRA patients than the controls.
CONCLUSION
The data of this study on Korean children with JRA suggests that HLA-DRB1*01 was associated with the susceptibility of JRA. The study should be extended to include larger numbers of patients.

Keyword

Juvenile rheumatoid arthritis; Human leukocyte antigen; HLA-DRB1

MeSH Terms

Adult
Alleles
Arthritis, Juvenile*
Child
HLA-DRB1 Chains
Humans
Leukocytes*
Phenotype
HLA-DRB1 Chains

Figure

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  Figure 1. HLA-DRB1 phenotype frequencies in JRA patients and control.

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  Figure 2. HLA-DRB1 phenotype frequencies in subtypes of JRA patients and controls.

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