Ann Rehabil Med.  2013 Jun;37(3):430-432. 10.5535/arm.2013.37.3.430.

A Case Report of Long-Term Bisphosphonate Therapy and Atypical Stress Fracture of Bilateral Femur

• Jo YR
• Kim HW
• Moon SH
• Ko YJ

• KMID: 2219542
• DOI: http://doi.org/10.5535/arm.2013.37.3.430

Abstract

Bisphosphonates are potent inhibitors of bone resorption and considered as a gold standard and are generally recommended as first-line therapy in patients with osteoporosis. Though bisphosphonates are shown to significantly reduce the risk of vertebral, non-vertebral and hip fractures, recent reports suggest a possible correlation between long-term bisphosphonate therapy and the occurrence of insufficiency fractures owing to prolonged bone turnover suppression. We report a patient with non-traumatic stress fractures of bilateral femoral shafts related to long-term bisphosphonate therapy indicating the need for a critical evaluation of patients with long-term bisphosphonate therapy.

Keyword

Osteoporosis; Bisphosphonates; Stress fracture

MeSH Terms

Bone Resorption
Diphosphonates
Femur
Fractures, Stress
Hip Fractures
Humans
Osteoporosis
Diphosphonates