Ann Dermatol.  2009 May;21(2):150-153. 10.5021/ad.2009.21.2.150.

A Case of Inflammatory Disseminated Superficial Porokeratosis in a Colon Cancer Patient

• Choi KH
• Kim TY

• KMID: 2219384
• DOI: http://doi.org/10.5021/ad.2009.21.2.150

Abstract

Disseminated superficial porokeratosis (DSP) is a specific disorder of keratinization. Genetic studies show that DSP is an autosomal dominant trait. Clinically, the lesions show a sharply demarcated and hyperkeratotic plaque with central atrophy. The lesions appear mainly in the extremities and generally develop with bilateral symmetry. Unusual cases of DSP accompanied by severe pruritus have been reported as "eruptive pruritic papular porokeratosis" or "inflammatory DSP." Histopathologically, inflammatory DSP is characterized by the presence of cornoid lamella with a dense infiltration of eosinophils and lymphocytes in the perivascular area of the upper dermis. Here we report a case of inflammatory DSP in a 84-year-old man with colon cancer who presented with multiple hyperpigmented atrophic macules.

Keyword

Colon cancer; Inflammatory disseminated superficial porokeratosis

MeSH Terms

Aged, 80 and over
Atrophy
Colon
Colonic Neoplasms
Dermis
Eosinophils
Extremities
Humans
Keratins
Lymphocytes
Porokeratosis
Pruritus
Keratins

Figure

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  Fig. 1 Disseminated brown annular plaques with hyperkeratotic borders on the trunk and extremities.

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  Fig. 2 (A) Histopathology of porokeratosis from the abdomen showing cornoid lamella; a column of parakeratotic cells (H&E stain, ×100). (B) Histopathology showing infiltrates with lymphocytes and eosinophils in the upper dermis and deeper dermis (H&E stain, ×200). (C) p53 staining showing strong nuclear reactivity on the basal layer of the lesion (labeled streptavidin-biotin-peroxidase complex) (×200).

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