Allergy Asthma Respir Dis.  2016 Jan;4(1):65-69. 10.4168/aard.2016.4.1.65.

Diffuse panbronchiolitis in an adolescent female

  • 1Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea.


Diffuse panbronchiolitis (DPB) is a progressive inflammatory respiratory disease of unknown cause mainly occurring in East Asian people. Studies on causes of the disease point to a genetic predisposition unique to Asians, but the cause remains unknown. If untreated, DPB progresses to bronchiectasis, respiratory failure, and death. The age of patients at onset of the disease varies from young to elderly people with a peak at 40-60 years. A few cases of DPB have been reported in Korean adults since 1992; however, the case of DPB in children is uncommon. Herein, we describe a 16-year-old girl with DPB who presented with chronic cough and sputum.


Diffuse panbronchiolitis; Child; Macrolides

MeSH Terms

Asian Continental Ancestry Group
Genetic Predisposition to Disease
Respiratory Insufficiency


  • Fig. 1 Serial change of chest x-ray (A) in 2009; 4 years before diagnosis (B) in 2013; at initial diagnosis (C) in 2014; before treatment (D) in 2015; a year after treatment.

  • Fig. 2 Chest computed tomography at initial diagnosis (A, B) and before treatment (C, D).


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