J Korean Ophthalmol Soc.  2014 Sep;55(9):1327-1333. 10.3341/jkos.2014.55.9.1327.

Difference in Subfoveal Choroidal Thickness between Two Spectral-Domain Optical Coherence Tomography Systems

• Kim JH
• Yu S
• Kim JS
• Lee KW
• Lee JH

• KMID: 2217116
• DOI: http://doi.org/10.3341/jkos.2014.55.9.1327

Abstract

PURPOSE
To determine the difference in subfoveal choroidal thickness between two spectral-domain optical coherence tomography (SD-OCT) systems in normal eyes and eyes with retinal diseases.
METHODS
Thirty-three normal eyes and 49 eyes with retinal disease (13 eyes with diabetic retinopathy, 28 eyes with epiretinal membrane and eight eyes with macular hole) were enrolled in the study. Subfoveal choroidal thicknesses were measured by 3 observers using the enhanced depth imaging technique of Heidelberg Spectralis(R) and the high-definition five-line raster scan of Cirrus HD-OCT(R) using calipers within the program. Differences between the measured values were analyzed with a paired t-test in PASW 18.0.
RESULTS
The mean age of normal eyes was 67.31 years, while eyes with diabetic retinopathy, epiretinal membrane and macular hole were aged 56.08 years, 70.00 years and 68.50 years, respectively. The mean subfoveal choroidal thickness of normal eyes was 237.61 +/- 104.60 microm for Spectralis and 239.52 +/- 92.08 microm for Cirrus and showed no significant difference (p = 0.397). Eyes with diabetic retinopathy, epiretinal membrane, and macular hole measured 267.46 +/- 74.91 microm, 236.79 +/- 84.16 microm and 209.63 +/- 86.71 microm for Spectralis, respectively, and 266.69 +/- 73.76 microm, 226.75 +/- 77.30 microm and 206.75 +/- 78.69 microm for Cirrus. They also showed no statistical difference (p > 0.05).
CONCLUSIONS
Subfoveal choroidal thickness measurements according to Heidelberg Spectralis(R) and Cirrus HD-OCT(R) in both normal eyes and eyes with retinal diseases showed no significant differences.

Keyword

Choroidal thickness; Enhanced depth image technique; High-definition scan; SD-OCT

MeSH Terms

Choroid*
Diabetic Retinopathy
Epiretinal Membrane
Retinal Diseases
Retinal Perforations
Tomography, Optical Coherence*

Figure

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  Figure 1. Optical coherence tomography (OCT) scans showing choroidal thicknesses of the same subject on two different systems. (A, B, C) An OCT image of subject on Heidelberg Spectralis® (Heidelberg Engineering, Heidelberg, Germany). Image averaging with the aid of eye tracking and enhanced depth imaging are used for choroidal visualization. Red line indicates choroidal thickness measurements taken perpendicularly from the outer edge of the hyper-reflective retinal pigment epithelium to the inner sclera at the fovea. (D, E, F) An OCT image of subject on Cirrus HD-OCT® (Carl Zeiss Meditec Inc., Dublin, CA). Image averaging is used for choroidal visualization. Red line indicates subfoveal choroidal thickness. ERM = epiretinal membrane; DR = diabetic retinopathy.

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  Figure 2. Scatterplots of measurements of each observer with two spectral domain optical coherence tomography. They show a significant positive correlation (p < 0.05) (A, B, C: Spectralis; D, E, F: Cirrus).

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  Figure 3. Bland-Altman plot for Spectralis versus Cirrus. Solid line indicates the average mean difference, whereas dotted lines delineate 95% confidence limits of agreement.

Reference

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