J Korean Ophthalmol Soc.  2013 May;54(5):728-735. 10.3341/jkos.2013.54.5.728.

Influence of Patent Ductus Arteriosus and Its Treatment on Retinopathy of Prematurity

• Yoon MH
• Baek WK
• Moon YS

• KMID: 2217038
• DOI: http://doi.org/10.3341/jkos.2013.54.5.728

Abstract

PURPOSE
This study investigated the influence of patent ductus arteriosus (PDA) and its treatment on incidence and progression of retinopathy of prematurity (ROP).
METHODS
The authors retrospectively reviewed the medical records of 408 infants who underwent screening examinations for ROP at the Neonatal Intensive Care Unit of our hospital.
RESULTS
The total incidence of ROP was 23.5% (96 out of 408) and the patients that needed treatment were 7.4% (30 out of 408). The mean birth weight and gestational age was 1406.1 grams and 30.67 weeks in patients without ROP, and 979.8 grams and 27.46 weeks in patients with ROP, respectively. In both total and very low birth weight (VLBW) patients, the incidence of ROP was higher in the PDA group than the non-PDA group, but the PDA group was an independent risk factor only in the VLBW group (p = 0.033). The incidence of threshold disease was not significantly different between the PDA and control groups (p = 0.757). There was no significant difference of incidence of ROP and threshold disease among the 3 treatment groups for PDA.
CONCLUSIONS
In VLBW patients, the presence of PDA increased the risk of ROP and its progression, thus more attention is needed for PDA patients. However, there was no significant difference in ROP incidence and progression according to different PDA treatment methods.

Keyword

Patent ductus arteriosus; PDA; Retinopathy of prematurity; Risk factor; Very low birth weight

MeSH Terms

Birth Weight
Diterpenes
Ductus Arteriosus, Patent
Gestational Age
Humans
Incidence
Infant
Infant, Newborn
Infant, Very Low Birth Weight
Intensive Care, Neonatal
Mass Screening
Medical Records
Retinopathy of Prematurity
Retrospective Studies
Risk Factors
Diterpenes

Figure

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  Figure 1. ROP incidence of PDA group and control group in VLBW patients. This illustration shows that VLBW patients with PDA have much higher risk of ROP than patients without ROP. ROP = retinopathy of prematurity; PDA = patent ductus arteriosus; VLBW = very low birth weight.

Reference

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