J Korean Ophthalmol Soc.  2013 Apr;54(4):651-654. 10.3341/jkos.2013.54.4.651.

Eccrine Ductal Carcinoma Arising in the Eyelid

• Kim TH
• Lee JH
• Ahn JH
• Woo KI
• Suh YL
• Kim YD

• KMID: 2216948
• DOI: http://doi.org/10.3341/jkos.2013.54.4.651

Abstract

PURPOSE
Eccrine ductal carcinoma is an extremely rare tumor that arises in the eccrine sweat glands. The authors of the present study describe a case of an eyelid mass diagnosed as eccrine ductal carcinoma.
CASE SUMMARY
A 74-year-old woman visited our institute with a 3-month history of a mass in the left medial canthus. The lesion appeared as a solitary nodule with central ulceration. A magnetic resonance imaging (MRI) of the orbit showed a relatively well enhanced 0.8 cm x 0.8 cm-sized ovoid soft tissue mass. A mass excision was performed under frozen section control. The tumor was completely excised with margin clearance and medial canthal reconstruction was performed. Histopathological examination revealed a tumor composed of numerous duct-like structures lined with pleomorphic cuboidal epithelium that was diagnosed as eccrine ductal carcinoma of the eyelid.
CONCLUSIONS
This is the first description of eccrine ductal carcinoma in a patient in Korea. The possibility of the eccrine ductal carcinoma should be considered in the differential diagnosis in an elderly patient with an eyelid mass.

Keyword

Eccrine ductal carcinoma; Eyelid tumor; Sweat gland tumor

MeSH Terms

Aged
Carcinoma, Ductal
Diagnosis, Differential
Epithelium
Eyelids
Female
Frozen Sections
Humans
Korea
Magnetic Resonance Imaging
Orbit
Sweat Glands
Ulcer

Figure

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  Figure 1. Clinical photograph showing a firm mass with central ulceration in the medial canthal area of the left eye.

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  Figure 2. (A) T1-weighted axial image demonstrating a poorly marginated mass with low signal intensity. (B) T2-weighted axial image demonstrating a heterogeneous high signal intensity in the left medial canthal area. (C) Contrast enhanced T1-weighted images demonstrating a relatively well enhancing soft tissue mass in the left medial canthal area.

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  Figure 3. (A) Intraoperative photography showing a widely excised lesion with large defect. (B) A medial canthal reconstruction using advancement flap.

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  Figure 4. Low-power magnification of tumor shows numerous duct-like structures lined by cuboidal epithelium (hematoxylin and eosin, ×;100).

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  Figure 5. High-power magnification reveals frequent mitotic figures and nuclear pleomorphism (hematoxylin and eosin, ×;400).

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