J Korean Ophthalmol Soc.  2012 Jan;53(1):151-156. 10.3341/jkos.2012.53.1.151.

Visual Prognosis of Leber's Hereditary Optic Neuropathy with T14484C Mitochondrial DNA Mutation in Koreans

• Kim MJ
• Park SS
• Hwang JM

• KMID: 2215258
• DOI: http://doi.org/10.3341/jkos.2012.53.1.151

Abstract

PURPOSE
In order to evaluate the clinical features and visual prognosis of Leber's hereditary optic neuropathy (LHON) associated with T14484C mitochondrial DNA (mtDNA) mutation in Korean patients.
METHODS
To evaluate the clinical feature of Korean LHON patients with T14484C mtDNA mutation, a retrospective chart review was performed on 14 patients who visited our clinic with the chief complaint of decreased visual acuity.
RESULTS
All of the 14 patients experienced a significant decrease in visual acuity during the follow-up period. Eight of these patients (57%) showed an improvement in visual acuity of 20/50 or better in one or both eyes, and the remaining six patients (43%) showed visual acuities of 20/200 or worse in both eyes at the final follow-up. When the symptoms aggravated, ten patients (71%) showed central scotoma or cecocentral scotoma. Eleven of 12 patients (92%) who had undergone the Ishihara color vision test showed dyschromatopsia in the aggravated stage. Four patients had dyschromatopsia and three patients had central scotoma in both eyes even after visual recovery. There were no statistically significant differences in the age of onset or the nadir of visual acuity between the good visual recovery group and the non-recovery group (p > 0.05).
CONCLUSIONS
Korean LHON patients with the T14484C mutation showed relatively good visual prognosis similar to those of the Caucasian or Japanese patients but with remaining dyschromatopsia or central scotoma after visual recovery.

Keyword

T14484C mutation; Koreans; Leber's hereditary optic neuropathy; Visual functional prognosis

MeSH Terms

Age of Onset
Asian Continental Ancestry Group
Color Vision
DNA, Mitochondrial
Eye
Follow-Up Studies
Humans
Optic Atrophy, Hereditary, Leber
Prognosis
Retrospective Studies
Scotoma
Visual Acuity
DNA, Mitochondrial

Figure

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  Figure 1 Changes in visual acuity of T14484C mutation group.

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