J Korean Ophthalmol Soc.  2012 Jan;53(1):120-126. 10.3341/jkos.2012.53.1.120.

Effect of Laser Photocoagulation and Intravitreal Bevacizumab Injection on Zone I Retinopathy of Prematurity

Affiliations
  • 1Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. eyegod@jnu.ac.kr

Abstract

PURPOSE
To evaluate the efficacy and safety of laser photocoagulation and intravitreal injection of bevacizumab in zone I ROP (retinopathy of prematurity) accompanied with plus signs.
METHODS
We performed a retrospective analysis of the records of 12 eyes of 7 premature infants with zone I ROP accompanied with plus signs, treated with diode laser photocoagulation and intravitreal injection of bevacizumab that were followed-up for at least 12 months.
RESULTS
Mean gestational age was 30 + 2 weeks, mean birth weight was 1437 +/- 478 g, mean follow-up period was 14.7 +/- 2.0 months and mean age of diagnosis was 36 + 3 weeks. Plus signs were disappeared after an average of 10.1 +/- 2.4 postoperative days in all 12 eyes. The outcome was favorable in 11 (91.7%) of 12 treated eyes after a minimum of 12 months of follow-up. No local or systemic complications were observed.
CONCLUSIONS
Laser photocoagulation and intravitreal injection of bevacizumab are effective and safe for treatment of zone I ROP accompanied with plus signs and require long-term follow-up.

Keyword

Bevacizumab; Laser photocoagulation; Retinopathy of prematurity

MeSH Terms

Antibodies, Monoclonal, Humanized
Birth Weight
Diterpenes
Eye
Follow-Up Studies
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Intravitreal Injections
Lasers, Semiconductor
Light Coagulation
Retinopathy of Prematurity
Retrospective Studies
Bevacizumab
Antibodies, Monoclonal, Humanized
Diterpenes

Figure

  • Figure 1 Case 2. Fundus findings at preoperative (A, B) and 12 days after diode laser photocoagulation and intravitreal bevacizumab injection (C, D). (A, C) Right eye, (B, D) left eye. (A, B) Zone I retinopathy of prematurity with severe plus disease and flat neovascularization. (C, D) Note retinopathy of prematurity regression with resolution of plus disease. More continued peripheral vascularization over the laser scar in temporal retina.

  • Figure 2 Case 5. Fundus findings at preoperative (A, B) and 10 days after diode laser photocoagulation and intravitreal bevacizumab injection (C, D). (A, C) Right eye, (B, D) left eye. (A, B) Zone I retinopathy of prematurity with very severe plus disease and severe flat neovascularization. (C, D) Note resolution of plus disease and flat neovascularization. More continued peripheral vascularization in temporal retina.


Cited by  1 articles

Effect of Primary Intravitreal Bevacizumab Injection on Stage 3 Retinopathy of Prematurity with Plus Signs
Sung Eun Kim, Tyler Hyung Taek Rim, Christopher Seungkyu Lee
J Korean Ophthalmol Soc. 2015;56(1):62-69.    doi: 10.3341/jkos.2015.56.1.62.


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