J Korean Ophthalmol Soc.  2010 Nov;51(11):1491-1498. 10.3341/jkos.2010.51.11.1491.

The Effect of Intravitreal Triamcinolone Acetonide and Bevacizumab Injection on Intraocular Pressure

• Park JS
• Ha SW
• Park SB

• KMID: 2213979
• DOI: http://doi.org/10.3341/jkos.2010.51.11.1491

Abstract

PURPOSE
To compare intraocular pressure (IOP) changes after intravitreal triamcinolone acetonide versus bevacizumab injection.
METHODS
IOP was measured in 40 patients who received an intravitreal injection of 0.1 ml triamcinolone and 40 patients who received 2 consecutive intravitreal injections of bevacizumab (0.05 ml and 0.1 ml). Patients were divided into three groups : 0.1 ml triamcinolone group (0.1 IVTA group), 0.05 ml bevacizumab group (0.05 IVB group), and 0.1 ml bevacizumab group (0.1 IVB group). IOPs were compared within groups at different time points (before, 1 day after, and 30 days after the injection) and between groups at the same time points.
RESULTS
In the 0.05 IVB and 0.1 IVB groups, IOP at 1 day after injection was significantly lower than before injection (P< 0.01, P = 0.03), and IOP at 30 days after injection was significantly higher than IOP at 1 day after injection (P < 0.01, P < 0.01). In the 0.1 IVTA group, IOP at 30 days after injection was significantly higher than before injection (P = 0.01). Between groups, IOP at 1 day after injection in the 0.05 IVB group was significantly lower than IOP in the 0.1 IVTA group (P = 0.03).
CONCLUSIONS
IOP was decreased at 1 day after intravitreal bevacizumab injection, whereas in intravitreal triamcinolone acetonide IOP elevation persisted after 1 month.

Keyword

Bevacizumab; Intraocular pressure; Triamcinolone acetonide

MeSH Terms

Antibodies, Monoclonal, Humanized
Humans
Intraocular Pressure
Intravitreal Injections
Triamcinolone
Triamcinolone Acetonide
Bevacizumab
Antibodies, Monoclonal, Humanized
Triamcinolone
Triamcinolone Acetonide

Figure

• 

  Figure 1. Comparison of intraocular pressure between groups at the same time of injection. There was significant difference between groups at POD 1 day (ANOVA; P = 0.043). * Indicates a statistically significant difference between 0.05 IVB group and 0.1 IVTA group at POD 1 day (Post hoc test; P = 0.033).

• 

  Figure 2. Comparison of intraocular pressure within groups at different time of injection. Symbols denote statistically significant difference between the two groups. * P＜ 0.001l; † P＜ 0.001l ‡ P = 0.035; § P = 0.008; ∏ P = 0.01.

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